Physical and chemical properties.
1. Appearance: white or off-white powder, odorless and tasteless.
2. Granularity: 20 mesh sieve rate is not less than 99%; 30 mesh sieve rate is not less than 95%.
3. False specific gravity: 0.5-0.6g/ml, specific gravity 1.2224.
4. Thermal stability.
Discoloration temperature:195-210°C Carbonization temperature:260-275°C
Softening temperature:130℃ It is clear and transparent solution in water below 38℃.
Gel temperature:above 40℃.
Important properties.
1. soluble in water and a variety of organic solvents at room temperature. Such as: anhydrous methanol, ethanol, isopropanol, propylene glycol, dichloromethane, also soluble in acetone, chloroform, toluene and fiber solvent, the solution is transparent.
It is also soluble in acetone, chloroform, toluene and fiber solvent, and the solution is transparent.
2. H-HPC is a good thermal
H-HPC is a good thermoplastic substance, with excellent film-forming properties, the film is very tough, good gloss, full elasticity.
3. the ash content is very low, so that the product has excellent adhesion, as an emulsion viscosity, very stable, and good dispersion.
4. H-HPC itself has no pharmacological effect, non-toxic, harmless to the physiology.
5. H-HPC is chemically inert, difficult to chemical reaction with other substances.
6. substituent distribution is more uniform, full, H-HPC antibacterial strong.
7. Low equilibrium wet content.
8. Because of its non-ionic nature, the product will not gel in acidic solution and shows excellent stability in a wide range of PH values.
9. The concentrated solution of H-HPC can form regular orientation liquid crystal.
10. H-HPC aqueous solution has a surface-active effect.
11. its aqueous solution with the rise and fall of temperature, through the reversible process of gelation and dissolution.
Application
1. used as a viscous agent: in the pharmaceutical field, this product is mainly used as a binder, such as tablets, granules, fine particles
material of the binder, generally 1-5% of the weight of the agent, choose RT-L or RT-J type.
2. used as film coating materials for tablets. HPC has excellent film-forming properties, the resulting film is tough and elastic, and can be compared with plasticizers.
With plasticizers and a comparison of high and low, by mixing with other anti-temperature coating agent, can further improve the performance of the film. Generally, RT-L type is used.
RT-L type.
3. used as elixir thickener, detergent additive and emulsion stabilizer. Generally used RT-M type.
4. can be used as a skeleton material for the preparation of skeleton sustained-release tablets, sustained-release pills and double-layer sustained-release tablets, generally use RT-M type.
5. used as ethanol occasions when the gel agent and used as ointment base material, generally use RT-M type.
Dissolve in water.
1.Dissolve in water.
A. Add H-HPC slowly into the vigorously stirred water until it is completely melted, if all the materials are added, it will be difficult to dissolve.
If all the material is added, it will be difficult to dissolve; B. Take 20% of the predetermined amount of water.
B. Take 20-30% of the predetermined amount of water and heat it to above 60℃, add H-HPC slowly under the condition of full stirring.
After all the H-HCP is added, then add the remaining 80-70% of water, it can be completely dissolved.
2.Dissolve in organic solvent.
Add H-HCP into organic solvent slowly under full stirring, it is difficult to dissolve if added at one time.
Packing, storage and transportation and precautions.
Packed in cardboard drums lined with polyethylene film bags, net weight 25kg per drum; storage and transportation precautions: sealed, strictly prohibit sun and rain, moisture-proof, and strictly prohibit the use of H-HCP in the environment.
Storage and transportation precautions: sealed, strictly prohibited from sunlight and rain, moisture-proof, strictly prohibited from contact with acid and alkali.