1-Methyl-3-(trifluoromethyl)-1H-pyrazol-5-ol CAS 122431-37-2

Description

1-Methyl-3-(trifluoromethyl)-1H-pyrazol-5-ol is a heterocyclic organic compound belonging to the pyrazole class. Structurally, it features a pyrazole ring substituted with a methyl group at the 1-position, a trifluoromethyl group at the 3-position, and a hydroxyl group at the 5-position, classifying it as a pyrazolol. The presence of the trifluoromethyl (CF3) group often imparts unique characteristics to molecules, such as increased metabolic stability, lipophilicity, and altered electronic properties. This compound typically appears as a white to off-white crystalline solid and is primarily utilized as a key building block or intermediate in the synthesis of more complex molecules, particularly in the pharmaceutical and agrochemical industries. Its specific arrangement of functional groups makes it a valuable precursor for developing compounds with targeted biological activities.

Properties

Property	Value
Chemical Name	1-Methyl-3-(trifluoromethyl)-1H-pyrazol-5-ol
CAS Number	122431-37-2
Molecular Formula	C5H5F3N2O
Molecular Weight	196.10 g/mol
Appearance	White to off-white crystalline powder or solid
Purity	≥98% (typical)
Melting Point	148-152 °C (typical, may vary)
Boiling Point	Not readily available; likely decomposes or boils at high temperature
Solubility	Soluble in many organic solvents (e.g., methanol, ethanol, DMSO, DMF). Sparingly soluble in water.
Stability	Stable under recommended storage conditions (cool, dry, and dark place)

Usage

1-Methyl-3-(trifluoromethyl)-1H-pyrazol-5-ol serves as a crucial intermediate in organic synthesis, particularly for creating specialized chemical entities. Its applications include:

• Pharmaceutical Synthesis: It is a valuable building block for the development of active pharmaceutical ingredients (APIs). Pyrazole derivatives are known for a wide range of biological activities, and the trifluoromethyl group can enhance drug efficacy and pharmacokinetic profiles. Examples of potential therapeutic areas include anti-inflammatory agents, analgesics, and compounds targeting the central nervous system.
• Agrochemical Development: This compound can be used in the synthesis of novel pesticides, herbicides, and fungicides. The trifluoromethyl-substituted pyrazole motif is found in several commercial agrochemicals, contributing to their potency and selectivity.
• Research Chemicals: Used in chemical research for developing new synthetic methodologies or as a precursor for novel compounds with potential applications in materials science or as ligands in coordination chemistry.

Contact Us Now!

If you need MSDS,TDS or sample testing, please email us at pharm@sinocurechem.com or use the website live chat to get prompt reply.