Description:
1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) is a strong, non-nucleophilic base widely used in organic synthesis and pharmaceutical manufacturing. It serves as a catalyst and reagent in acylation, alkylation, and elimination reactions. Known for its high reactivity and low volatility, DBU is a go-to compound in industrial and research chemistry.
Properties:
Property
Value
Chemical Name
1,8-Diazabicyclo[5.4.0]undec-7-ene
CAS Number
6674-22-2
Molecular Formula
C9H16N2
Molecular Weight
152.24 g/mol
Appearance
Colorless to pale yellow liquid
Boiling Point
261–262 °C
Density
1.02 g/cm³ at 25 °C
Purity
≥ 98% (commercial grade)
Solubility
Miscible with most organic solvents
Usage:
DBU is widely used as a base in organic chemistry for:
Pharmaceutical synthesis (e.g., synthesis of active pharmaceutical ingredients)
Polymer chemistry
Catalysis in esterification and transesterification reactions
Peptide synthesis as a coupling reagent
Its non-nucleophilic nature makes it ideal for sensitive reactions requiring strong but selective bases.
Packaging and Transportation:
1,8-Diazabicyclo[5.4.0]undec-7-ene is packaged in sealed HDPE bottles or drums to ensure safety and stability. It is shipped in compliance with international transport regulations for chemical substances.
Storage:
Store in a tightly closed container, in a cool, dry, and well-ventilated area. Keep away from heat, moisture, and incompatible substances.
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