1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) CAS 6674-22-2

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Description:

1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) is a strong, non-nucleophilic base widely used in organic synthesis and pharmaceutical manufacturing. It serves as a catalyst and reagent in acylation, alkylation, and elimination reactions. Known for its high reactivity and low volatility, DBU is a go-to compound in industrial and research chemistry.

Properties:

Property

Value

Chemical Name

1,8-Diazabicyclo[5.4.0]undec-7-ene

CAS Number

6674-22-2

Molecular Formula

C9H16N2

Molecular Weight

152.24 g/mol

Appearance

Colorless to pale yellow liquid

Boiling Point

261–262 °C

Density

1.02 g/cm³ at 25 °C

Purity

≥ 98% (commercial grade)

Solubility

Miscible with most organic solvents

Usage:

DBU is widely used as a base in organic chemistry for:

  • Pharmaceutical synthesis (e.g., synthesis of active pharmaceutical ingredients)

  • Polymer chemistry

  • Catalysis in esterification and transesterification reactions

  • Peptide synthesis as a coupling reagent

Its non-nucleophilic nature makes it ideal for sensitive reactions requiring strong but selective bases.

Packaging and Transportation:

1,8-Diazabicyclo[5.4.0]undec-7-ene is packaged in sealed HDPE bottles or drums to ensure safety and stability. It is shipped in compliance with international transport regulations for chemical substances.

Storage:

Store in a tightly closed container, in a cool, dry, and well-ventilated area. Keep away from heat, moisture, and incompatible substances.

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