Product Description:
3,3-Dimethyl-2-oxobutyric acid (CAS 815-17-8), also known as Trimethylpyruvic acid or Pivaloylformic acid, is an alpha-keto acid. It typically appears as a white or colorless to almost white or almost colorless powder, lump, or clear liquid, and is soluble in water. This organic compound serves as a valuable intermediate in various chemical syntheses, particularly in the pharmaceutical industry (e.g., as an intermediate for Atazanavir, an anti-AIDS drug) and in biochemical research, including studies on enzyme inhibition and metabolic pathways.
Product Properties:
Property Value Chemical Name 3,3-Dimethyl-2-oxobutyric acid CAS Number 815-17-8 Molecular Formula C₆H₁₀O₃ Molecular Weight Approximately 130.14 g/mol Appearance White or Colorless to Almost white or Almost colorless powder, lump, or clear liquid Melting Point Approximately 90.5 °C Boiling Point Approximately 80 °C / 15mmHg (or 182.4 °C at 760 mmHg) Density Approximately 1.06 – 1.1 g/cm³ Solubility Soluble in water and ether Synonyms Trimethylpyruvic acid, Pivaloylformic acid, tert-Butylglyoxylic acid, 3,3-Dimethyl-2-oxobutanoic acid Product Usage:
3,3-Dimethyl-2-oxobutyric acid is utilized in several key applications:
- Pharmaceutical Intermediate: It is a crucial building block in the synthesis of various pharmaceutical compounds, notably as an intermediate in the production of antiviral drugs like Atazanavir.
- Biochemical Research: Used in laboratory settings for studying enzyme kinetics, metabolic pathways, and as an inhibitor in specific biological processes (e.g., studies related to pantothenate synthetase in tuberculosis research).
- Organic Synthesis: Serves as a versatile reagent in organic chemistry for the preparation of more complex molecules and chiral compounds, such as L-tert-leucine.
- Nutritional Additives and Gene Engineering Reagents: Explored for potential use in these areas, although less common than its role in pharmaceutical synthesis.
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