Product Description
Dithioerythritol (DTE), with CAS number 6892-68-8, is a potent reducing agent and a crucial reagent in biochemistry and molecular biology. It is the erythro isomer and an epimer of dithiothreitol (DTT). Like DTT, DTE is used to protect sulfhydryl groups from oxidation and to reduce disulfide bonds in proteins and peptides, thereby preventing intramolecular and intermolecular disulfide bond formation. Its ability to maintain proteins in their reduced state makes it invaluable for enzyme assays, electrophoresis, and various protein purification protocols.
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Product Properties
Property Value IUPAC Name (2S,3S)-1,4-bis(sulfanyl)butane-2,3-diol Synonym DTE, Erythro-1,4-dimercapto-2,3-butanediol CAS Number 6892-68-8 Chemical Formula Molar Mass 154.25 g/mol Appearance White crystalline powder or solid Purity Typically ≥99% Solubility Soluble in water, ethanol, and acetone. Product Usage
- Protein Biochemistry: Used as a strong reducing agent to cleave disulfide bonds in proteins, helping to denature them for analysis by techniques like SDS-PAGE.
- Enzyme Assays: Added to buffers to maintain enzymes in their active, reduced state by preventing the oxidation of critical cysteine residues.
- Cell Lysis: Included in lysis buffers to disrupt protein disulfide bonds and solubilize proteins from cellular extracts.
- Redox Chemistry: Serves as a standard thiol reagent for studying redox-sensitive cellular pathways and protein functions.
- Antioxidant: Functions as an effective scavenger of reactive oxygen species, protecting biological molecules from oxidative damage in vitro.
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