Product Overview
2,2′-Azobis(2-methylpropionamidine) dihydrochloride, commonly known as AAPH, is a research chemical with the CAS number 2997-92-4. It is primarily used in scientific studies, particularly for understanding drug oxidation and initiating polymerization reactions. This compound is a white to light yellow crystalline powder, making it easy to handle in lab settings.
Uses and Benefits
AAPH is a free radical generator, which means it helps scientists study how drugs and other substances react under oxidative stress. It’s also used as a polymerization initiator for materials like acrylic and vinyl, which could be relevant for developing new materials. Its role in pharmaceutical research, especially in drug oxidation studies, makes it a key tool for labs working on drug development.
Specifications
Here are some key specifications:
- Molecular Formula: C8H20Cl2N6
- Molecular Weight: 271.19 g/mol
- Melting Point: 175-177°C
- Solubility: Soluble in water, acetone, dioxane, methanol, ethanol, and DMSO
- Storage: Should be kept at 0-6°C due to thermal instability
- Water Solubility: 176.2 g/L at 20°C
These details ensure researchers can use it safely and effectively in their experiments.
Product Details: In-Depth Description
AAPH, with the CAS number 2997-92-4, is a chemical compound extensively used in scientific research. Its molecular formula is C8H20Cl2N6, and it has a molecular weight of 271.19 g/mol, as confirmed by PubChem (2,2′-Azobis(2-methylpropionamidine) dihydrochloride | C8H20Cl2N6 | CID 76344). Physically, it appears as a white to light yellow crystalline powder, with a melting point of 175-177°C, as noted on ChemicalBook (2,2′-Azobis(2-methylpropionamidine) dihydrochloride | 2997-92-4). It is soluble in various solvents, including water, acetone, dioxane, methanol, ethanol, and DMSO, enhancing its utility in laboratory settings.
The primary uses of AAPH include serving as a free radical generator and a polymerization initiator, particularly for acrylic, vinyl, and allyl monomers, as detailed on Sigma-Aldrich (2,2 -Azobis(2-methylpropionamidine) granules, 97 2997-92-4). It is particularly valuable in pharmaceutical research for studying the oxidation of drugs, acting as a model oxidant in small molecule and protein therapeutics, as described on Wikipedia (2,2′-Azobis(2-amidinopropane) dihydrochloride – Wikipedia). Additionally, it has been used in experiments on linoleic acid to induce oxidation, helping to explore the antioxidant effects of natural phenolics, which is an interesting application extending beyond pharmaceuticals into materials science.
Chemically, AAPH is thermally unstable and requires storage at 0-6°C to maintain stability, with a water solubility of 176.2 g/L at 20°C, as per ChemicalBook. Safety considerations are crucial, as it is sensitive to heat and light, incompatible with strong oxidizing agents and acids, and can decompose to produce hazardous substances like hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide, and ammonia, as noted in various supplier datasheets.
Physical and Chemical Properties: Detailed Specifications
To provide a comprehensive view, the following table summarizes the physical and chemical properties, sourced from ChemicalBook and other reliable platforms:
| Property | Value |
|---|---|
| Name | 2,2′-Azobis(2-methylpropionamidine) dihydrochloride |
| CAS Number | 2997-92-4 |
| Molecular Formula | C8H20Cl2N6 |
| Molecular Weight | 271.19 g/mol |
| Appearance | White to light yellow crystalline powder |
| Melting Point | 175-177 °C (lit.) |
| Solubility | Soluble in water, acetone, dioxane, methanol, ethanol, DMSO |
| Storage Temperature | 0-6°C |
| Water Solubility | 176.2 g/L at 20°C |
| Vapor Pressure | 0 Pa at 20°C |
Note: Density was initially listed as 0.42 g/cm³ on ChemicalBook, but due to its unusually low value for a solid, and lack of confirmation from other sources like PubChem or Sigma-Aldrich, it has been omitted to ensure accuracy.
Applications and Benefits: Extended Insights
AAPH’s applications extend beyond basic research into specific areas of interest. Its role as a free radical generator makes it essential for studying oxidative stress in drug development, particularly in understanding how drugs degrade under oxidative conditions. This is critical for ensuring drug stability and efficacy, making it a staple in pharmaceutical labs. Additionally, its use in polymerization reactions is vital for materials science, potentially leading to innovations in polymer-based pharmaceuticals or medical devices.
An interesting application is its use in experiments with linoleic acid, where it induces oxidation to study the synergistic or antagonistic effects of natural phenolics, as noted on Wikipedia. This could appeal to researchers in nutrition or food science, expanding the potential customer base beyond pharmaceuticals.
Safety and Handling: Important Considerations
Given its thermal instability and sensitivity to heat and light, proper storage at 0-6°C is essential, as is handling with care to avoid contact with strong oxidizing agents and acids. The potential for decomposition into hazardous substances like hydrogen chloride and nitrogen oxides underscores the need for proper lab safety protocols, which should be highlighted for users to ensure compliance and safety.
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