Description
Benfotiamine is a synthetic, lipid-soluble derivative of thiamine (Vitamin B1). Unlike natural thiamine, which is water-soluble, benfotiamine’s fat-soluble nature allows for significantly higher absorption and bioavailability in the body. Once absorbed, it is converted into thiamine. Benfotiamine is primarily known for its ability to increase thiamine levels in tissues more effectively than thiamine itself. It is often studied and used for its potential benefits in conditions related to thiamine deficiency and for supporting nerve health, particularly in the context of diabetic complications. It works by enhancing the activity of the enzyme transketolase, which plays a crucial role in glucose metabolism and protecting cells from the harmful effects of high blood sugar.
Properties
Property Value Chemical Name S-Benzoylthiamine O-monophosphate Synonyms Benfotiamin, Milgamma, Biotamin, Berithiamine CAS Number 22457-89-2 Molecular Formula C19H23N4O6PS Molecular Weight 466.45 g/mol Appearance White to off-white crystalline powder Solubility Sparingly soluble in water, soluble in organic solvents like ethanol Form Lipid-soluble derivative of Thiamine (Vitamin B1) Usage
Benfotiamine is utilized in various applications due to its enhanced bioavailability and therapeutic potential:
- Dietary Supplements: Commonly used as a dietary supplement to increase thiamine levels, particularly for individuals at risk of thiamine deficiency or those seeking to support nerve health and healthy blood sugar metabolism. It is often marketed for diabetic neuropathy and general nerve support.
- Pharmaceutical Applications: Investigated and used in the management of complications associated with diabetes, such as diabetic neuropathy (nerve damage), nephropathy (kidney damage), and retinopathy (eye damage). It’s also explored for its potential in alcoholic neuropathy and other thiamine-responsive conditions.
- Research: Used in scientific research to study the mechanisms of thiamine metabolism, the effects of advanced glycation end products (AGEs), and its neuroprotective properties.
- Nutraceuticals: Incorporated into advanced nutraceutical formulations aimed at metabolic support, antioxidant effects, and promoting healthy aging.
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