1. Description
Bis(trimethylsilyl)trifluoroacetamide (BSTFA), CAS 25561-30-2, is a highly effective silylation reagent widely utilized in pharmaceutical analysis. Belonging to the class of silylating agents, it is primarily employed for the derivatization of polar functional groups in active pharmaceutical ingredients (APIs), metabolites, and related compounds. Key benefits include enhancing compound volatility and thermal stability for gas chromatography (GC) and mass spectrometry (MS) analysis, enabling sensitive and accurate quantification.
2. Properties Table
Property Value Product Name Bis(trimethylsilyl)trifluoroacetamide (BSTFA) CAS Number 25561-30-2 Molecular Formula C$_{8}$H$_{18}$F$_{3}$NOSi$_{2}$ Molecular Weight 257.40 g/mol Appearance Clear, colorless liquid Purity >98% (GC Grade) Boiling Point ~45-50 °C @ 14 mmHg Density ~0.96 g/mL at 20°C Refractive Index ~1.383 at 20°C 3. Usage
- Used extensively for derivatizing hydroxyl, carboxyl, amine, and thiol groups in pharmaceutical compounds prior to GC or GC-MS analysis.
- Essential reagent in quality control labs for analyzing API purity, stability studies, and identifying impurities or degradation products.
- Applied in pharmacokinetic studies for the trace-level quantification of drugs and their metabolites in biological matrices (e.g., plasma, urine).
4. Packaging & Transportation
Packaged under an inert atmosphere (Nitrogen or Argon) in sealed amber glass vials or bottles to prevent moisture contamination and degradation. Shipped in compliance with IATA and DOT regulations for hazardous materials (Flammable Liquid, Corrosive). Appropriate hazard labeling and documentation provided.
5. Storage
Store refrigerated at 2-8°C in a dry, well-ventilated area away from moisture and incompatible substances. Keep container tightly sealed under an inert atmosphere.
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