Description
Chlorodiphenylphosphine (CAS 1079-66-9) is a highly reactive organophosphorus compound used primarily as a chemical intermediate and reagent in organic synthesis. It serves as a key precursor for introducing the diphenylphosphino () group and for synthesizing various phosphine ligands, which are crucial in homogeneous catalysis, including steps within pharmaceutical manufacturing routes. Due to its sensitivity to air and moisture, it requires careful handling and storage. As a reliable supplier, we provide high-quality Chlorodiphenylphosphine for your advanced synthesis needs.
Properties
Property Description CAS Number 1079-66-9 Chemical Formula (or ) Synonyms Diphenylchlorophosphine, Diphenylphosphinous chloride Appearance Liquid Color Colorless to light yellow Odor Pungent, irritating Reactivity Highly reactive with water, alcohols; Air-sensitive Solubility Soluble in many aprotic organic solvents (e.g., THF, toluene, ); Reacts with protic solvents Density Approx. Key Characteristic Reactive intermediate, Ligand precursor, Moisture & Air Sensitive, Corrosive Usage
Chlorodiphenylphosphine is a valuable reagent primarily employed in:
- Synthesis of Phosphine Ligands: Used extensively to create tertiary phosphines and other phosphorus-containing ligands essential for metal-catalyzed reactions (e.g., cross-coupling, hydrogenation) often employed in fine chemical and pharmaceutical synthesis.
- Chemical Intermediate: Acts as a building block for introducing the diphenylphosphino () functional group onto various organic molecules.
- Reagent in Organic Synthesis: Utilized in various transformations, including as a precursor for phosphonium salts used in reactions like the Wittig olefination.
- Fine Chemical Manufacturing: Serves as a key raw material in multi-step synthetic processes.
Packaging and Transportation
Reflecting its air and moisture sensitivity, Chlorodiphenylphosphine is supplied in specialized, securely sealed containers, such as septum-sealed bottles (e.g., Sure/Seal™ type) or cylinders, under an inert atmosphere (typically nitrogen or argon). Transportation strictly adheres to regulations for hazardous materials, recognizing its corrosive, water-reactive, and air-sensitive nature.
Storage
Store Chlorodiphenylphosphine under a dry, inert atmosphere (nitrogen or argon) in tightly sealed containers. Keep in a cool, dry, well-ventilated area specifically designated for reactive and hazardous chemicals. Store away from water, alcohols, oxidizing agents, heat, sparks, and open flames. Strict adherence to handling procedures for air- and moisture-sensitive compounds is required.
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