1. Description
Croscarmellose Sodium (CAS 74811-65-7) is an essential pharmaceutical excipient, functioning as a highly effective superdisintegrant in solid dosage forms. It is an internally cross-linked form of sodium carboxymethylcellulose (NaCMC), a modified cellulose polymer. Its key benefit lies in its ability to rapidly absorb water and swell significantly, promoting fast disintegration and dissolution of tablets and capsules.
2. Properties Table
Property Value Product Name Croscarmellose Sodium CAS Number 74811-65-7 Chemical Class Cross-linked Sodium Carboxymethylcellulose Appearance White, fibrous, free-flowing powder Solubility Insoluble in water; Swells rapidly pH (1% Aqueous Dispersion) Loss on Drying Pharmacopeial Compliance Conforms to USP/NF, Ph. Eur., JP standards 3. Usage
- Widely used as a superdisintegrant in tablet formulations (direct compression, wet granulation, dry granulation) at typical concentrations of .
- Incorporated into capsule formulations to facilitate rapid disintegration of the powder plug upon shell opening.
- Enhances dissolution profiles of poorly soluble drugs by breaking down the solid dosage form quickly.
4. Packaging & Transportation
Supplied in well-closed, sealed containers, typically multi-wall paper bags or fiber drums with polyethylene liners to protect against moisture. Classified as non-hazardous for standard road, air, and sea transportation.
5. Storage
Store in airtight containers in a cool, dry environment away from high humidity. Croscarmellose Sodium is hygroscopic; proper storage is crucial to maintain its disintegration properties.
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