Product Description
Estriol is one of the three main estrogens produced by the human body, alongside estradiol and estrone. It is considered a weaker estrogen and is produced in significant amounts during pregnancy, primarily by the placenta. Estriol is used pharmaceutically, often in hormone replacement therapy (HRT) for menopausal symptoms, particularly for localized vaginal atrophy. It is valued for its more targeted effects and potentially lower risk profile compared to stronger estrogens.
Product Properties
Property Description Chemical Formula C18H24O3 Molecular Weight 288.38 g/mol Appearance White to off-white crystalline powder Solubility Practically insoluble in water; soluble in alcohol, acetone, and other organic solvents Type Estrogen hormone Primary Source Produced by the placenta during pregnancy; can be synthesized Mechanism of Action Binds to estrogen receptors, though with lower affinity than estradiol Product Usage
Estriol has several therapeutic applications, primarily related to estrogen deficiency:
- Menopausal Hormone Therapy (HRT): It is commonly used to treat symptoms of menopause, especially atrophic vaginitis (vaginal dryness, itching, and irritation) and related urinary tract issues. It is often preferred for local applications (creams, pessaries) due to its weaker systemic effects.
- Skin Creams: Estriol is sometimes incorporated into topical creams for its potential benefits in improving skin elasticity and hydration, and reducing wrinkles, particularly in postmenopausal women.
- Compounded Medications: It is frequently used in compounded bioidentical hormone replacement therapy (BHRT) formulations, tailored to individual patient needs.
- Research Applications: Estriol is also used in scientific research to study estrogen activity, hormone metabolism, and related physiological processes.
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