Product Description
Estrone (E1) is one of the three primary naturally occurring estrogens in humans, along with estradiol (E2) and estriol (E3). It is a weaker estrogen and is predominantly produced by the ovaries and adrenal glands, and peripherally from androstenedione in adipose tissue. Post-menopause, estrone becomes the main estrogen in circulation. Pharmaceutically, it has been used in hormone replacement therapy (HRT) to alleviate menopausal symptoms, though its use has become less common in favor of other estrogens or combination therapies due to its metabolic profile.
Product Properties
Property Description Chemical Formula C18H22O2 Molecular Weight 270.37 g/mol Appearance White to creamy white crystalline powder Solubility Practically insoluble in water; soluble in alcohol, acetone, dioxane, and vegetable oils Type Estrogen hormone Primary Source Ovaries, adrenal glands, peripheral conversion from androstenedione Mechanism of Action Binds to estrogen receptors, influencing gene transcription in target tissues Product Usage
Estrone has been historically used in medicine, primarily for:
- Menopausal Hormone Therapy (HRT): It was used to manage symptoms of menopause such as hot flashes, vaginal atrophy, and osteoporosis. It can be administered via various routes, including oral, transdermal, or injection.
- Treatment of Female Hypogonadism: Used to help develop and maintain female secondary sexual characteristics in cases of ovarian failure or removal.
- Palliative Treatment: In some specific cases, it has been used in the palliative treatment of certain hormone-responsive cancers, such as prostate cancer and breast cancer in appropriately selected patients.
- Research Applications: Estrone and its metabolites are studied in endocrinology research to understand hormone pathways, metabolism, and their roles in health and disease.
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