Hydroxypinacolone Retinoate CAS 893412-73-2

Description

Hydroxypinacolone Retinoate (HPR), CAS 893412-73-2, is a cosmetic grade ester of retinoic acid. It is considered a next-generation retinoid that offers high efficacy similar to prescription retinoic acid but with significantly lower irritation potential. Unlike other retinol derivatives that need to undergo metabolic conversion steps in the skin to become active, Hydroxypinacolone Retinoate can bind directly to retinoid receptors. This direct action allows it to deliver potent anti-aging and skin-renewing benefits, such as improving the appearance of fine lines, wrinkles, skin texture, and pigmentation, without the common side effects associated with traditional retinoids like redness, peeling, and sensitivity. It is often marketed under trade names like Granactive Retinoid, typically supplied as a solution in a solvent like Dimethyl Isosorbide.

Properties

Property	Value
CAS Number	893412-73-2
INCI Name	Hydroxypinacolone Retinoate
Molecular Formula	C26​H38​O3​
Molecular Weight	Approximately 398.58 g/mol
Appearance	Typically supplied as a yellowish liquid solution (often 10% active in a solvent) or a solid.
Solubility	Soluble in esters, Dimethyl Isosorbide (DMI), and other cosmetic solvents. Insoluble in water.
Stability	More stable than many other forms of retinoids, particularly when protected from light and air.
Form	Often available as a solution (e.g., in Dimethyl Isosorbide) for ease of formulation.
Typical Use Level	0.1% – 2% of a 10% active solution (equating to 0.01% – 0.2% active HPR) in cosmetic formulations.

Usage

Hydroxypinacolone Retinoate is primarily used in cosmetic and skincare products for its potent retinoid activity with reduced irritation. Its key applications include:

• Anti-Aging Products: It is highly effective in formulations designed to reduce the appearance of fine lines, wrinkles, and improve skin elasticity and firmness.
  • Example: Serums, night creams, eye creams, and anti-aging moisturizers.
• Skin Texture Refinement: Helps to improve overall skin texture, making it smoother and more even-toned.
  • Example: Exfoliating serums, skin resurfacing treatments.
• Hyperpigmentation Reduction: Can aid in diminishing the appearance of dark spots, sun spots, and other forms of hyperpigmentation.
  • Example: Brightening serums, spot treatments.
• Acne and Blemish Control: Due to its ability to promote cell turnover and regulate sebum, it can be beneficial in products for acne-prone skin.
  • Example: Anti-acne lotions, clarifying serums.
• Gentle Retinoid Alternative: Suitable for individuals with sensitive skin who may not tolerate traditional retinol or retinoic acid.
  • Example: Skincare lines specifically formulated for sensitive skin seeking retinoid benefits.

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