L-Carnitine 50%
CAS: 461-05-2
SPECIFICATION:
Description: White crystal
Assay: ≥50±1%
Heavy metal: ≤10ppm
Arsenic: ≤2ppm
Molecular Formula | C7H16ClNO3 |
Molar Mass | 197.66 |
Melting Point | 197-199°C |
Specific Rotation(α) | -0.2~+0.2°(20℃/D)(c=5,H2O) |
Water Solubility | SOLUBLE |
Solubility | Aqueous Base (Slightly), Methanol (Slightly, Heated), Water (Sparingly, Sonicate |
Appearance | White powder |
Color | White to almost white |
Merck | 14,1849 |
BRN | 4163212 |
PH | 1.8-2.5 (100g/l, H2O) |
Storage Condition | Store below +30°C. |
Stability | Hygroscopic |
Sensitive | Hygroscopic |
MDL | MFCD00011904 |
Physical and Chemical Properties | Melting point 190-205°C water-SOLUBLE SOLUBLE |
Use | For medicine, aquatic feed add nutrients, etc |
In vitro study | The main role of L-carnitine is to shuttle long-chain fatty acids across the inner mitochondrial membrane. After L-carnitine and acyl-CoA become acyl-carnitine by activation of carnitine palmitoyl transferase (CPT)-I, the transported acyl-carnitine is changed into acyl-CoA by CPT-II in the mitochondria matrix. Palmitoyl-CoA-induced mitochondrial respiration is increased by L-carnitine treatment, and then is accelerated by the presence of ADP. This acceleration is induced by treatment with L-carnitine in a concentration-dependent manner, and is saturated at 5 mM L-carnitine. Pretreatment with L-carnitine augments Nrf2 nuclear translocation, DNA binding activity and heme oxygenase-1 (HO-1) expression in H 2 O 2 -treated HL7702 cells. L-carnitine protects HL7702 cells against H 2 O 2 -induced cell damage through Akt-mediated activation of Nrf2 signaling pathway. |
In vivo study | L-carnitine is found to down-regulate the ubiquitin proteasome pathway and increase IGF-1 concentrations in animal models. L-carnitine administration for 2 weeks of hindlimb suspension alleviates the decrease in weight and fiber size in the soleus muscle. In addition, L-carnitine suppresses atrogin-1 mRNA expression, which has been reported to play a pivotal role in muscle atrophy. Simultaneous treatment with L-carnitine attenuates the renal fibrosis (which correlated with a reduction of plasma TGF-β1 levels) and the pro-oxidative and proinflammatory status reported in L-NAME groups, with a concomitant increase in the expression of PPAR-γ. |