Piperazine
Properties
Molecular Formula C4H10N2
Molecular weight 86.13
CAS No. 110-85-0
EINECS No. 203-808-3
Melting point 107-111 ºc
Boiling Point 146-148 ºc
Flash Point 65 ºc
Water solubility 150 g/l (20 ºc)
Piperazine is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. Piperazine exists as small alkaline deliquescent crystals with a saline taste.
The piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group. group.
Uses
It is mainly used in the production of piperazine phosphate and piperazine citrate, as well as fluphenazine, diclofenac sodium and rifampicin, which are used as anthelmintics. Piperazine hexahydrate is dissolved in ethanol, added with glacial acetic acid and stirred and cooled to precipitate piperazine acetate, which is used in the synthesis of hormone drug sodium hydroprednisone phosphate.
Preparation method
1. from chloroethanol by ammonia, cyclic synthesis of piperazine hydrochloride, and then neutralised with sodium hydroxide to produce piperazine hexahydrate.
2. Piperazine is made from chloroethanol by ammoniation and cyclisation.
Safety Information
Do not inhale the dust.
In case of inadvertent contact with eyes, flush immediately with plenty of water and seek medical advice.
Wear appropriate protective clothing, gloves and goggles or mask.
Avoid release into the environment.