Trifluoromethanesulfonic acid CAS 1493-13-6

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1. Description

Trifluoromethanesulfonic acid (TFMS), CAS 1493-13-6, is an exceptionally potent organic superacid widely employed in pharmaceutical research and manufacturing. Its primary role is as a highly efficient catalyst for various organic transformations crucial in drug synthesis, such as alkylations, acylations, and polymerizations. Key benefits include its remarkable acidity (approx. 1000 times stronger than sulfuric acid), excellent thermal and chemical stability, and its non-oxidizing nature compared to other strong mineral acids, ensuring cleaner reactions and higher yields in sensitive API production pathways.

2. Properties Table

Property Value
Product Name Trifluoromethanesulfonic acid
CAS Number 1493-13-6
Synonyms Triflic acid, TFMS, TfOH
Molecular Formula
Molecular Weight 150.08 g/mol
Appearance Colorless to pale yellow fuming liquid
Purity ≥99%
Density approx. 1.696 g/mL (at 25 °C)
Boiling Point approx. 162 °C (at 760 mmHg)
Acidity (pKa) approx. -14.7

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