Trifluoromethanesulfonyl Chloride CAS 421-83-0

Details

  • Product Name: Trifluoromethanesulfonyl Chloride

  • CAS Number: 421-83-0

  • Chemical Formula: CF₃SO₂Cl

  • Intended Use: Widely used in the synthesis of triflate derivatives and other organic transformations, particularly in pharmaceutical intermediate production.

  • Safety Consideration: This reagent is corrosive and reacts violently with water. Appropriate safety protocols and personal protective equipment (PPE) are mandatory during handling.

Properties

Below is a table summarizing the key properties:

Property Value
Chemical Name Trifluoromethanesulfonyl Chloride
CAS Number 421-83-0
Molecular Formula CF₃SO₂Cl
Molecular Weight Approximately 168.5 g/mol
Appearance Colorless to pale yellow liquid
Boiling Point Approximately 65°C*
Density ~1.5 g/cm³
Reactivity Highly reactive; moisture sensitive

Usage

Trifluoromethanesulfonyl Chloride is primarily employed as an electrophilic reagent in organic synthesis. It is used to introduce triflyl groups into molecules, forming triflate derivatives that serve as versatile intermediates for various chemical transformations. This reagent is especially valuable in pharmaceutical research and industrial chemistry where high purity and controlled reactivity are critical.

Packaging and Transportation

  • Packaging:
    The product is typically supplied in tightly sealed, corrosion-resistant containers, such as glass bottles or specially lined drums, to ensure chemical integrity and safety during storage and transport.

  • Transportation:
    The compound is classified as a hazardous material and must be transported in compliance with all relevant regulations. It is shipped under controlled conditions, maintaining temperature and avoiding exposure to moisture, with appropriate labeling and documentation according to international transport standards.

Storage

  • Storage Conditions:
    Store in a cool, dry, and well-ventilated area. The product should be kept away from direct sunlight, moisture, and incompatible materials (such as water or strong bases). Ensure that storage facilities meet hazardous material handling standards.

  • Handling:
    Due to its highly reactive nature, it is imperative to use proper PPE (gloves, goggles, and lab coats) during handling. Emergency procedures should be in place in case of accidental exposure or spills.

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