18β-Glycyrrhetinic Acid CAS 471-53-4

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Product Description:

18β-Glycyrrhetinic Acid is a pentacyclic triterpenoid derivative of the beta-amyrin type, primarily obtained from the hydrolysis of glycyrrhizin, which is a major sweet-tasting compound found in licorice root (Glycyrrhiza glabra). It is a white to yellowish crystalline powder known for its various biological activities, including anti-inflammatory, anti-viral, and anti-tumor effects. This compound is widely studied and utilized in pharmaceutical and cosmetic industries.

18β-Glycyrrhetinic Acid CAS 471-53-4

Product Properties:

Property Value

Chemical Formula

C₃₀H₄₆O₄

CAS Number

471-53-4

Molar Mass

470.68 g/mol

Appearance

White to yellowish crystalline powder

Odor

Odorless or slight characteristic odor

Melting Point

Approximately 292-295 °C (558-563 °F; 565-568 K) (decomposes)

Solubility

Practically insoluble in water; soluble in ethanol, chloroform, acetic acid

Optical Rotation

+145° to +165° (in ethanol)

Purity (Typical)

≥98%

Product Usage:

18β-Glycyrrhetinic Acid has diverse applications across several industries due to its significant biological properties:

  • Pharmaceuticals:

    • Used as an active ingredient in topical preparations for its anti-inflammatory properties, for example, in creams for dermatitis and eczema.

    • Investigated for its potential anti-viral effects, including activity against viruses like herpes simplex and hepatitis.

    • Studied for its hepato-protective and anti-ulcer activities.

    • Acts as a precursor in the synthesis of other pharmacologically active compounds, such as carbenoxolone.

  • Cosmetics and Skincare:

    • Incorporated into skincare products for its soothing, anti-irritant, and skin-conditioning effects; for instance, in lotions for sensitive skin or after-sun products.

    • Used in formulations aimed at improving skin brightness and reducing redness.

    • Found in oral care products for its potential benefits in maintaining gum health.

  • Food Industry:

    • Sometimes used as a flavoring agent or sweetener enhancer in certain food products, leveraging its origin from licorice.

  • Research Applications:

    • Serves as a valuable research chemical for investigating various cellular mechanisms and potential therapeutic targets.

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