Tetrabutylphosphine chloride CAS 2304-30-5

Description

Tetrabutylphosphine chloride, CAS 2304-30-5, is a quaternary phosphonium salt. It is characterized by a central phosphorus atom bonded to four butyl groups, forming the tetrabutylphosphonium cation ([P(C4​H9​)4​]+), with chloride (Cl−) as the counter anion. This compound typically appears as a white to off-white crystalline solid and is known to be hygroscopic. Tetrabutylphosphine chloride serves as a versatile reagent in organic synthesis, often employed as a phase transfer catalyst (PTC) to facilitate reactions between reactants in different phases. It is also used as a source of the tetrabutylphosphonium cation, as a precursor for the synthesis of other phosphonium salts or phosphine ligands, and can be a component in ionic liquid formulations. While the request mentions “pharmaceutical product,” its primary applications are in chemical synthesis and research, potentially including the synthesis of pharmaceutical intermediates, rather than as a direct therapeutic agent.

Properties

Property	Value
CAS Number	2304-30-5
Chemical Name	Tetrabutylphosphonium chloride; Tetrabutylphosphanium chloride
Common Acronym	TBPC; TBPCl
Molecular Formula	C16​H36​PCl
Molecular Weight	294.88 g/mol
Appearance	White to off-white crystalline powder or solid; often hygroscopic
Melting Point	Approximately 78−83∘C (can vary with purity and hydration state)
Solubility	Soluble in water, alcohols (e.g., ethanol, methanol), dichloromethane, chloroform; less soluble in non-polar organic solvents.
Stability	Relatively stable, but hygroscopic; should be stored in a cool, dry place under inert atmosphere if possible.
Purity/Grades	Typically available in reagent grade or high purity (e.g., >97%, >98%, >99%).

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